Evaluation of Prothrombin Response to Vitamin K as Liver Function Test
نویسنده
چکیده
The prothrombin of the blood is elaborated in the liver. Andrus et al. (1939), and Warren and Rhoads (1939) produced experimental evidence in support, of this hypothesis. By total and partial hepatectomy in animals they produced a profound reduction in plasma prothrombin concentration which was unaffected by treatment with vitamin K and bile salts. It has been found essential to have vitamin K for the production of prothrombin, the level of which falls in subjects with vitamin K deficiency. The exact role which vitamin K plays in the formation of prothrombin is yet to be decided. Is it a necessary constituent of prothrombin or does it act as a stimulus to the liver for the formation of prothrombin ? Evidence is against the former contention, since pure prothrombin preparations do not have
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The Prothrombin Response to the Parenteral Administration of Large Doses
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